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Helene HA Dermal Filler
Helene HA Dermal Filler by ACMEDI Korea — 4 viscosity grades (Shine · Smooth · Mid · All) with 20 mg/mL HA. Micro-Bead Cross-Linking technology. Ultra-low BDDE residue (< 2 ppm) and endotoxin (< 0.05 EU/mg). CE-marked, ISO 13485:2016. Select the variant for your target depth.
$36.50
Quantity discounts
| Quantity | Discount | Price |
|---|---|---|
| 5-9 | 3% | $35.41 |
| 10-19 | 5% | $34.68 |
| 20-Unlimited | 8% | $33.58 |
Helene HA Filler — ACMEDI Korea Micro-Bead Cross-Linked HA Filler, 4 Viscosity Grades
What it is
Helene is a four-tier Korean HA filler system manufactured by ACMEDI Korea Co., Ltd., engineered around patented Micro-Bead Cross-Linking technology. The line spans from superficial skin hydration (Shine) to structural deep-tissue volumization (All), unified by 20 mg/mL HA, ultra-low residual BDDE (< 2 ppm), and EDQM-certified raw materials. Select the variant in the Type dropdown above based on target depth and indication.
How it works
Built on ACMEDI’s patented Micro-Bead Cross-Linking technology — the HA gel is structured as discrete cross-linked microbeads of controlled particle size (100-500 μm range across the four variants). This bead architecture delivers high hydrophilicity (cited by manufacturer as 300% baseline hydration uplift) plus stable G’ viscoelasticity in the 250-350 Pa range. Ultra-low residual BDDE (< 2 ppm) and endotoxin (< 0.05 EU/mg) levels target reduced inflammation and hypersensitivity risk.
Helene variant guide
All four variants share the same 20 mg/mL HA backbone and Micro-Bead Cross-Linking technology. Differ by particle size, target depth, and needle gauge. Select the matching Type in the dropdown above.
| Variant | Particle Size | Target Depth | Primary Use | Gauge |
|---|---|---|---|---|
| Helene Shine | 100–200 μm | Superficial dermis (1–2 mm) | Fine lines, periorbital rhytids, skin hydration | 30G / 32G |
| Helene Smooth | 200–300 μm | Deep dermis (18–20 mm) | Moderate wrinkles, NLF, marionette lines | 27G / 30G |
| Helene Mid | 300–400 μm | Mid–deep dermis | Mid-zone wrinkles, lip body, perioral | 27G |
| Helene All | 400–500 μm | Subcutaneous / periosteal (23–25 mm) | Severe volume restoration, structural contouring | 25G / 27G |
Technical specifications
Detail for clinical, regulatory, and shipping reference. Headline figures shown in the panel above.
| Manufacturer | ACMEDI KOREA Co., Ltd. · South Korea |
| HA source | Non-animal bacterial fermentation · EDQM-certified raw materials |
| Cross-linker | BDDE (< 2 ppm residue) · Patented Micro-Bead Cross-Linking technology |
| Endotoxin level | < 0.05 EU/mg |
| Hydrophilicity | 300% baseline hydration uplift (manufacturer data) |
| Packaging | Pre-filled sterile syringe · triple-layer protective packaging · batch-tracked |
| Storage | 2–25 °C · do not freeze · protect from direct sunlight |
| Reversibility | Dissolvable with hyaluronidase if needed |
| Intended use | Licensed medical professionals only |
FAQ
Which Helene variant should I order?+
Choose by particle size matching the target depth. Shine (100-200 μm) for superficial fine lines and skin hydration. Smooth (200-300 μm) for moderate wrinkles, NLF, marionettes. Mid (300-400 μm) for mid-zone wrinkles, lip body, perioral. All (400-500 μm) for severe volume loss requiring subcutaneous/periosteal placement. Many practices stock Smooth + All for the most common 80% of cases.
What is Micro-Bead Cross-Linking technology?+
ACMEDI’s patented HA crosslinking process forms discrete cross-linked microbeads of controlled particle size, rather than a continuous gel matrix. The bead architecture allows fine-tuning of particle size per variant (100 μm to 500 μm) for matched injection depth, while maintaining high hydrophilicity and stable G’ viscoelasticity. Ultra-low residual BDDE (< 2 ppm) and endotoxin (< 0.05 EU/mg) target reduced inflammation and hypersensitivity risk.
Can Helene variants be layered in one session?+
Yes. A common full-face protocol layers Helene All for deep volume (cheek, chin, jawline), Helene Smooth for nasolabial folds and marionettes, Helene Mid for lip body and perioral, and Helene Shine for surface finishing on fine lines. All four share the same HA backbone and Micro-Bead architecture, so tissue integration is consistent across layers.
How does Helene compare to HyalDew (similar 4-tier system)?+
Both are Korean HA fillers with 4-tier variant systems (Shine/Fine/Mid/All for HyalDew; Shine/Smooth/Mid/All for Helene). HyalDew uses MCL Technology (Multi-stage Cross-Linking — nested microbeads of varying sizes). Helene uses Micro-Bead Cross-Linking (discrete bead architecture per variant). Helene emphasizes low BDDE residue (< 2 ppm) and high hydrophilicity as differentiators; HyalDew emphasizes the patented microbead nesting structure. Practitioners often choose between them based on injection feel preference and pricing.
Where to buy Helene wholesale and how to verify authenticity?+
Wholesale through MJS Medicals for licensed healthcare professionals. To verify authenticity: (1) ACMEDI Korea branding on outer carton; (2) CE mark visible; (3) HA concentration matches 20 mg/mL; (4) triple-layer protective packaging with batch-tracked distribution label; (5) intact tamper-evident sterile seal; (6) variant matches the dropdown selection (Shine/Smooth/Mid/All).
Who is qualified to inject Helene?+
Licensed physicians, dermatologists, plastic surgeons, and trained aesthetic practitioners only. Buyers self-certify professional status at checkout.
Safety
Helene-specific: Wide particle-size range across variants (100 μm Shine → 500 μm All) means depth-variant matching is critical. Placing Helene All too superficially risks palpable nodules and Tyndall effect; Shine placed too deep wastes product through rapid resorption. 24-hour allergy patch test recommended before first administration per manufacturer guidance.
Prescription medical device. Contraindicated in pregnancy, lactation, active autoimmune conditions, history of streptococcal disease, hypersensitivity to HA or gram-positive bacterial proteins, active local infection, and concurrent anticoagulant therapy. Aspirate before injection; keep hyaluronidase on hand for reversal.
Last reviewed: May 2026 · Source verification: ACMEDI Korea Co., Ltd. · CE Mark · EDQM-certified raw materials · ISO 13485:2016
| ProType |
Helene All, Helene Mid, Helene Shine, Helene smooth |
|---|
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