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Juvederm Ultra 4 (2 x 1ml)
Juvederm Ultra 4 Lidocaine by Allergan is a high-precision dermal filler containing 24 mg/ml hyaluronic acid and 0.3% lidocaine. Clinically proven to correct deep nasolabial folds, enhance cheek/chin volume, and improve facial contours with results lasting up to 12 months (92% patient satisfaction in trials). Its dual-action formula minimizes discomfort while maintaining a low adverse event rate (≤2.8%).
$228.00
Juvederm Ultra 4 2×1ml — Allergan Hylacross HA Filler for Deep Wrinkles & Cheek Volume
What it is
Ultra 4 is the densest tier of Allergan’s Hylacross collection — designed for deep nasolabial folds, cheek volume augmentation, chin projection, and lip volumization. The high-density Hylacross gel provides the most structural lift in the Ultra range.
How Hylacross Technology works
Hylacross Technology (cohesive monophasic cross-linked HA). Hylacross is Allergan’s foundational cross-linking process — producing a highly cohesive, smooth monophasic gel with predictable injection flow and excellent tissue integration. Hylacross HA is fully biodegradable, broken down naturally by the body over 9–12 months.
Technical specifications
Detail for clinical, regulatory, and shipping reference. Headline figures shown in the panel above.
| Manufacturer | Allergan Aesthetics (AbbVie subsidiary) |
| Manufacturing Origin | Haute Savoie, France |
| HA Source | Streptococcus equi bacterial fermentation, non-animal origin |
| Cross-linker | BDDE · Hylacross Technology |
| Excipients | Phosphate buffer pH 7.2 |
| Volumizing Capacity | 4/5 |
| CE Mark | 0344 (syringe) · 0123 (needles) |
| Storage | 2–25 °C · do not freeze · protect from direct sunlight |
| Shelf life | 24 months unopened (verify lot label) |
| Reversibility | Dissolvable with hyaluronidase if needed |
| Intended use | Licensed medical professionals only |
FAQ
How is Ultra 4 different from Voluma (deep-tissue Vycross)?+
Both target deep tissue volume but use different technologies. Ultra 4 (Hylacross) is the densest Ultra-range product, lasting up to 12 months. Voluma (Vycross) is engineered specifically for very deep cheek/temple work with a different HA molecular weight mix (10% high + 90% low MW) and lasts up to 18 months. Practitioners often choose Voluma for premium long-duration cheek work and Ultra 4 for moderate-budget cheek/NLF work.
Where is Juvederm manufactured?+
Juvederm is manufactured by Allergan Aesthetics (an AbbVie subsidiary) at their facility in Haute Savoie, France. This is the original Allergan production site for the global Juvederm range, including the Hylacross-based Ultra collection. CE 0459 Class III medical device certification.
How long does this product last?+
Duration is Up to 12 months depending on injection site, patient metabolism, and lifestyle. Mobile facial zones (lips, perioral) typically resorb faster than static zones (cheek, temple). Individual hyaluronidase activity also influences longevity.
What’s the difference between Hylacross and Vycross technology?+
Both are Allergan-proprietary HA cross-linking technologies. Hylacross (used in the Ultra range) is the foundational process producing a smooth cohesive monophasic gel — best known for predictable injection flow and tissue integration. Vycross (used in Voluma/Volbella/Volift/Volux/Volite) is the newer technology combining low and high molecular weight HA chains for higher cross-linking efficiency, lower HA concentration, and longer duration. Vycross products generally last longer (12–18 months) than Hylacross products (up to 12 months).
Where to buy wholesale and how to verify authenticity?+
Wholesale through MJS Medicals for licensed healthcare professionals. To verify authenticity: (1) Allergan / Juvederm branding on packaging with Haute Savoie France origin marking; (2) CE 0459 mark visible; (3) HA concentration matches 24 mg/mL; (4) batch number with traceability labels included per box; (5) intact tamper-evident sterile seal; (6) French / English language packaging.
Who is qualified to inject?+
Licensed physicians, dermatologists, plastic surgeons, and aesthetic practitioners with Juvederm-specific training only. Allergan provides global injector training programs. Buyers self-certify professional status at checkout.
Safety
This product-specific: Deep dermal placement near facial artery branches — vascular vigilance essential. Aspirate before injection; use cannula in danger zones around nasolabial fold, cheek, and chin where deep arterial branches run.
Prescription medical device (CE 0459 Class III). Contraindicated in known hypersensitivity to HA, lidocaine, or Gram-positive bacterial proteins; severe allergies / anaphylaxis history; pregnancy / breastfeeding; autoimmune disorders; active local infection; and concurrent anticoagulant therapy. Aspirate before injection; keep hyaluronidase on hand for reversal. Vision abnormalities (rare but serious) have been reported in some Juvederm products — strict avoidance of off-label injection into highly vascular areas (glabella, periorbital, nose) required.
Last reviewed: May 2026 · Source verification: hcp.juvederm.com · Allergan Aesthetics · CE 0459 Class III · ISO 13485:2016
Related Products
Juvederm Voluma Lidocaine (2 x 1ml)
Juvederm Voluma Lidocaine by Allergan is an dermal filler containing 20mg/ml hyaluronic acid and 0.3% anesthetic. Clinically proven to restore cheek/chin volume (94% patient satisfaction) and reduce nasolabial folds, with visible results within 24 hours. Features VYCROSS™ technology for 12-18 month longevity, 68% HA retention at 1 year, and 82% pain reduction during injection. Ideal for facial contouring and collagen stimulation.
Juvederm Ultra 2 (2 X 0.55ml)
Juvederm Ultra 2 is an hyaluronic acid filler (24 mg/ml HA + 0.3% lidocaine) specifically engineered for correcting moderate nasolabial folds, perioral lines, and lip augmentation. Clinical trials demonstrate 92% patient satisfaction at 4-week follow-up, with 68% reduction in injection discomfort versus non-anesthetic fillers. Utilizing VYCROSS™ technology, it provides 9-12 month duration through optimized cross-linking density (20% high/80% low molecular weight HA chains) while maintaining 94% natural tissue mobility post-treatment.
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